| 题名 | Peripheral primitive neuroectodermal tumor of the ovary confirmed by CD99 immunostaining, karyotypic analysis, and RT-PCR for EWS/FLI-1 chimeric mRNA. | | 作者 | Kawauchi S, Fukuda T, Miyamoto S, Yoshioka J, Shirahama S, Saito T, Tsukamoto N. | | 杂志 | Am J Surg Pathol. | | 年|卷|期 | 1998 Nov;22(11):1417-22. | | 页码 | 1998 Nov;22(11):1417-22. | | 链接 | https://www.ncbi.nlm.nih.gov/pubmed/?term=Peripheral+primitive+neuroectodermal+tumor+of+the+ovary+confirmed+by+CD99+immunostaining%2C+karyotypic+analysis%2C+and+RT-PCR+for+EWS%2FFLI-1+chimeric+mRNA. |
Am J Surg Pathol. 1998 Nov;22(11):1417-22.
Peripheral primitive neuroectodermal tumor of the ovary confirmed by CD99 immunostaining, karyotypic analysis, and RT-PCR for EWS/FLI-1 chimeric mRNA.
Kawauchi S, Fukuda T, Miyamoto S, Yoshioka J, Shirahama S, Saito T, Tsukamoto N.
Abstract
We report a case of peripheral primitive neuroectodermal tumor (pPNET), which belongs to the PNET/Ewing's sarcoma family, arising in the left ovary of a 29-year-old woman. Microscopically, the tumor was composed of solid nests and sheets of monotonous, primitive, small round cells with a few rosettes, making it difficult to distinguish from small cell carcinoma of the ovary. Immunohistochemically, the tumor cells showed intense cell-membranous immunoreactivity for MIC2 protein (CD99). A short-term cell culture and karyotypic analysis revealed the tumor to possess a balanced t(11;22)(q24;q12) chromosomal translocation that is highly specific for tumors of the PNET/Ewing's sarcoma family. In addition, EWS/FLI-1 chimeric mRNA that originated from the characteristic chromosomal translocation was detected by reverse transcription-polymerase chain reaction. These results confirmed the diagnostic validity of the present tumor being a pPNET, thus raising the possibility that in the past, pPNETs which have arisen in the ovary may have been mistakenly diagnosed as small cell carcinomas of the ovary.
PMID: 9808135 | 
发表于 2016-10-17 15:55:05
淘帖
收藏
顶
踩
