- 收听数
- 8
- 性别
- 男
- 听众数
- 22
- 最后登录
- 2024-11-7
- 学历
- 博士
- QQ
 - UID
- 1120
- 阅读权限
- 90
- 帖子
- 7380
- 精华
- 0
- 在线时间
- 4423 小时
- 注册时间
- 2012-11-4
  
- 科研币
- 235
- 速递币
- 1329
- 娱乐币
- 8364
- 文献值
- 1667
- 资源值
- 22
- 贡献值
- 6
|
速递书局
| 封面: |
 |
| 题名: |
Vaccines for Pandemic Influenza |
| 作者: |
Compans, Richard W, Orenstein, Walter A. |
| 出版社: |
Springer-Verlag Berlin Heidelberg |
| 出版日期: |
2009 |
| ISBN: |
Hardcover ISBN 978-3-540-92164-6 Softcover ISBN 978-3-642-24240-3 |
| 附属页: |
齐全 |
| 书签: |
有 |
| 格式: |
清晰PDF |
| 内容简介: |
Recent years have seen unprecedented outbreaks of avian influenza A viruses. In particular, highly pathogenic H5N1 viruses have not only resulted in widespread outbreaks in domestic poultry, but have been transmitted to humans resulting in numerous fatalities. The rapid expansion in their geographic distribution and the possibility that these viruses could acquire the ability to spread from person to person raise the risk that such a virus could cause a global pandemic with high morbidity and mortality. An effective influenza vaccine represents the best approach to prevent and control such an emerging pandemic. However, current influenza vaccines are directed at existing seasonal influenza viruses, which have limited antigenic relationships to the highly pathogenic H5N1 strains. Concerns about pandemic preparedness have greatly stimulated research activities to develop effective vaccines for pandemic influenza viruses, and to overcome the limitations inherent in current approaches to vaccine production and distribution. These limitations include the use of embryonated chicken eggs as the substrate for vaccine production; which is time-consuming and could involve potential biohazards in growth of new virus strains. Other limitations include the requirement that the current inactivated influenza vaccines be administered using needles and syringes, requiring trained personnel, which could be a bottleneck when attempting to vaccinate large populations in mass campaigns. In addition, the current inactivated vaccines which are delivered by injection elicit limited protective immunity in the upper respiratory tract where the infection process is initiated. Most of these limitations of the current vaccines are being addressed by research on novel approaches to vaccine development and delivery that are described in many of the chapters in this volume. |
| 求助帖链接: |
http://www.expaper.cn/forum.php?mod=viewthread&tid=245362 |
本帖子中包含更多资源
您需要 登录 才可以下载或查看，没有帐号？快速注册
|
发表于 2020-5-12 08:57:59
淘帖
收藏
顶
踩
发表于 2020-5-15 12:30:50
