10 速递币求助一化合物的合成

chengcj2008

检索目的	实验
检索方式	reaxys
CAS号	27996-86-7
关键词	4-(1H-1,2,4-Triazol-1-yl)benzaldehyde
分子式	C9H7N3O
结构式	有
检索年份	不限

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mistero

商品化试剂的话还要自己合成吗，看看能不能买到呗

mistero

话说这个试剂是有卖的？

mistero

3.1. General experimental procedure for the synthesis of 4-(1H-[1,2,4]-triazol-1-yl)benzaldehyde (3)
To a solution of 4-fluorobenzaldehyde (1) (5.0 g, 40.32 mmol) and 1H-[1,2,4]-triazole (2) (3.3 g, 47.82 mmol) in DMF (50 mL) was added powdered K2CO3 (6.67 g, 48.38 mmol). The mixture was stirred at 120 °C for 12 h. Reaction mixture was warmed up at room temperature and quenched with water. It was extracted with ethylacetate (2 × 150 mL). The combined organic fractions were washed with water (100 mL) followed to brine solution (100 mL) and dried over anhydrous Na2SO4. Solvent was removed under reduced pressure and purification was done by flash chromatography (hexane:ethylacetate, 3:1 elution) to give 4-(1H-[1,2,4]-triazol-1-yl)benzaldehyde as a off-white solid (3) (5.0 g, 72% yield). 1H NMR (CDCl3) δ (ppm): 8.01–8.10 (4H, m), 8.15 (1H, s, triazole-H), 9.43 (1H, s, ArH), 10.10 (1H, s, CHO). m/z 173 (M+).

这篇文章的3.1部分http://www.sciencedirect.com/sci ... i/S0223523408005886

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