鍗佸ぇ鍊煎緱鍏虫敞鐨勪笁鏈熶复搴婅瘯楠岀殑閲嶇鏂拌嵂

myyounger

澶у瀷鐢熺墿鎶€鏈叕鍙稿湪缇庡浗浜夌浉鎻愪氦鏂拌嵂娉ㄥ唽鐢宠锛岃繖浜涗骇鍝侀殢鍚庝細鑾峰噯涓婂競銆傚尰鑽競鍦虹爺绌舵満鏋凟valuatePharma绮鹃€夊叏鐞冮《绾р參鏈熶复搴婅瘯楠岃嵂鐗╋紝鍙戠幇澶у叕鍙糕€滈噸纾呯偢寮光€濈骇鏂拌嵂绔炰簤渚濇棫婵€鐑堬紝鐧炬椂缇庢柦璐靛疂銆侀粯娌欎笢銆佽禌璇鸿彶銆佽緣鐟炪€佽鍗庛€佺綏姘忛兘鏈変骇鍝佸湪鍒椼€?

NO.1Nivolumab

鍏徃锛氱櫨鏃剁編鏂借吹瀹?

鐮斿彂闃舵锛氣參鏈?

鑽悊绫诲埆锛氭姉绋嬪簭鎬ф浜″洜瀛?1(PD-1)鍗曞厠闅嗘姉浣?

2020骞撮攢閲忥細60.1浜跨編鍏?

妫€鏌ョ偣鍙椾綋娌荤枟鑽墿瀵笷DA绗竴涓壒鍑嗘枃鍙风殑浜夊ず姣旇禌绔炰簤鍙皳婵€鐑堛€傝绫昏嵂鐗╅€氳繃鍏嶇柅绯荤粺鎶戝埗鐧岀粏鑳烇紝鍦ㄤ复搴婄爺绌朵腑鍏锋湁鏄庢樉鐩婂锛屾垚涓鸿繎骞存潵鏈€鍙楀叧娉ㄧ殑鐧岀棁娌荤枟鑽墿銆傜櫨鏃剁編鏂借吹瀹濈殑Nivolumab宸插湪鏃ユ湰鑾锋壒锛屾垚涓哄叏鐞冪涓€涓鏌ョ偣鍙椾綋娌荤枟鑽墿銆?

NO.2MK-3475

(pembrolizumab)

鍏徃锛氶粯娌欎笢

鐮斿彂闃舵锛氭彁浜や笂甯傜敵璇?

鑽悊绫诲埆锛氭姉绋嬪簭鎬ф浜″洜瀛?1(PD-1)鍗曞厠闅嗘姉浣?

2020骞撮攢閲忥細40.6浜跨編鍏?

MK-3475(pembrolizumab)鏃犵枒鏄唬琛ㄩ粯娌欎笢鐮斿彂娼滃姏鐨勪笉浜岄€夋嫨銆侳DA鎺堜簣璇ヨ嵂娌荤枟鏅氭湡榛戣壊绱犵槫鐨勭獊鐮存€х枟娉曡瀹氥€傚鏋滆幏鎵癸紝MK-3475灏嗘垚涓烘柊涓€绫诲厤鐤鏌ョ偣璋冭妭鍓備腑棣栦釜鎶桺D-1鎶椾綋銆?

NO.3Obeticholicacid

鍏徃锛欼ntercept鍏徃

鐮斿彂闃舵锛氣參鏈?

鑽悊绫诲埆锛氭硶灏奸唶X鍙椾綋(FXR)婵€鍔ㄥ墏

2020骞撮攢閲忥細29.9浜跨編鍏?

鐢辩編鍥藉浗绔嬪崼鐢熺爺绌堕櫌璧勫姪Obeticholicacid鐨勨叀b鏈熶复搴婄爺绌惰揪鍒颁富瑕佺粓鐐癸紝Intercept鍒惰嵂鍏徃閬傚湪浠婂勾鍒濆姞蹇簡璇ヨ嵂鐨勫紑鍙戦€熷害銆傛鍓嶏紝鎶曡祫鑰呭Obeticholicacid涓€浜涗弗閲嶇殑鍓綔鐢ㄦ姤鍛婂績瀛樻媴蹇э紝鑰屽叾鈪㈡湡娌荤枟鍘熷彂鎬ц儐姹佹€ц倽纭寲涔愯鐨勬暟鎹啀娆¤琛屼笟鎶曡祫鑰呴噸鐕冨笇鏈涳紝涓轰笂甯傜敵璇峰瀹氬熀纭€銆?

NO.4Palbociclib

鍏徃锛氳緣鐟?

鐮斿彂闃舵锛氣參鏈?

鑽悊绫诲埆锛氱粏鑳炲懆鏈熻泲鐧戒緷璧栨€ф縺閰?CDK)4鍜?鎶戝埗鍓?

2020骞撮攢閲忥細29.5浜跨編鍏?

鍦ㄧ粡鍘嗕簡鍏徃鍘嗗彶涓婅妯℃渶澶х殑鐮斿彂閲嶇粍涔嬪悗锛屼綔涓哄埗鑽法澶达紝杈夌憺鏂拌嵂鐮斿彂绠＄嚎鏄惧緱寮傚父鍗曡杽銆侾albociclib鏄緣鐟炲眻鎸囧彲鏁板€煎緱楠勫偛鐨勬柊鑽箣涓€銆備粖骞?鏈堬紝杈夌憺鍩轰簬鑹ソ鐨勨叀鏈熻瘯楠屾暟鎹彁浜や簡Palbociclib涓婂競鐢宠銆?

NO.5RG7446

鍏徃锛氱綏姘?

鐮斿彂闃舵锛氣參鏈?

鑽悊绫诲埆锛氭姉绋嬪簭鎬ф浜″洜瀛?1閰嶄綋-1(PD-L1)鍗曞厠闅嗘姉浣?

2020骞撮攢閲忥細29.3浜跨編鍏?

鍐嶆鍥炲埌鐢ㄤ簬鐧岀棁娌荤枟鐨勬鏌ョ偣鎶戝埗鍓傞鍩燂紝鍒嗘瀽甯堜滑瀵圭綏姘忕殑RG7446鍚屾牱淇濇寔涔愯銆傝櫧鐒堕粯娌欎笢鍜岀櫨鏃剁編鏂借吹瀹濈殑浜夊ず宸蹭娇杩欎竴棰嗗煙鏄惧緱寮傚父婵€鐑堬紝鑰岀綏姘忎竴鐩撮粯榛樻墽琛岃嚜宸辩殑寮€鍙戣鍒掞紝涓庡悎浣滀紮浼寸爺鍙慚PDL3280A/RG7446銆?

NO.6Ledipasvir/Sofosbuvir

鍏徃锛氬悏鍒╁痉绉戝

鐮斿彂闃舵锛氭彁浜や笂甯傜敵璇?

鑽悊绫诲埆锛氫笝鍨嬭倽鐐庢牳鑻種S5A鍜孨S5B鑱氬悎閰舵姂鍒跺墏

2020骞撮攢閲忥細28浜跨編鍏?

鍚夊埄寰风瀛﹀杽浜庡垱鏂帮紝浣嗘柊鑽笂甯傚悗浠锋牸鍚屾牱涓嶈彶锛孲ovaldi(sofosbuvir)灏辨槸鏈€鏄庢樉鐨勬渚嬨€備綔涓烘柊涓€浠ｄ笝鍨嬭倽鐐庣粍鍚圠edipasvir/Sofosbuvir锛岀敤浜庢不鐤楃柧鐥呬富瑕佺棁鐘躲€傚悏鍒╁痉宸插崰棰嗘姉鑹炬粙鐥呮瘨鑽墿甯傚満锛屽苟鎵胯灏嗙户缁叏閫熸帹杩涗笝鑲濇柊鑽紑鍙戙€?

NO.7DCVax-L

鍏徃锛氳タ鍖楃敓鐗╂不鐤?

鐮斿彂闃舵锛氣參鏈?

鑽悊绫诲埆锛氱檶鐥囩柅鑻?

2020骞撮攢閲忥細20.4浜跨編鍏?

浣滀负鐧岀棁鐤嫍锛孌CVax-L鍏呮弧浜嗕簤璁€備竴浜涘垎鏋愬笀瀵瑰叾骞朵笉鐪嬪ソ锛屼富瑕佸洜涓哄畠鏄竴绉嶅熀浜庢爲绐佺姸缁嗚優鎶€鏈殑鐧岀棁鐤嫍锛岀洰鍓嶅競鍦轰笂瀵瑰叾鍙嶅簲涓嶇儹鐑堛€傝繕鏈変汉鍥犺鍏徃閲囧彇瀹氭湡鎷涘嫙涓埆瀵硅嵂鐗╂湁绉瀬鍙嶅簲鎮ｈ€呬綔涓哄叿鏈夊箍娉涚枟鏁堢殑璇佹嵁鑰屽績瀛樿川鐤戙€?

NO.8VX-809ivacaftor

鍏徃锛歏ertex

鐮斿彂闃舵锛氣參鏈?

鑽悊绫诲埆锛氬泭鎬х氦缁村寲璺ㄨ啘鐢靛璋冭妭鍓?CFTR)鐭鍓?

2020骞撮攢閲忥細19浜跨編鍏?

Vertex鎶婅祵娉ㄦ娂鍦ㄥ鏂瑰埗鍓俈X-809ivacaftor涓娿€傛嵁Vertex琛ㄧず锛屾墍鏈?涓嵂鐗╃粍锛屽寘鎷?椤规櫄鏈熻瘯楠宭umacaftor缁?CFTR鐭鍓俈X-809)鍜孠alydeco(ivacaftor)杈惧埌浜嗕富瑕佺粓鐐?琛￠噺鑲哄姛鑳界殑鐢ㄥ姏鍛兼皵閲忔垨瀹圭Н鎸囨爣)銆?

NO.9LCZ696

鍏徃锛氳鍗?

鐮斿彂闃舵锛氣參鏈?

鑽悊绫诲埆锛欰T1鍙椾綋鑴戝暋鑲介叾(ARNI)鎶戝埗鍓?

2020骞撮攢閲忥細13浜跨編鍏?

鍦ㄥ績琛€绠＄柧鐥呴鍩燂紝璇哄崕鐨剆erelaxin铏界劧閬亣澶辫触锛屼絾LCZ696鏈夋湜鎵浆璐ュ眬銆傚熀浜庝护浜轰俊鏈嶇殑涓湡鐤楁晥鏁版嵁骞朵笖宸茶揪鍒颁富瑕佺粓鐐癸紝浠婂勾3鏈?1鏃ワ紝鏁版嵁鐩戞祴濮斿憳浼?DMC)涓€鑷村缓璁彁鍓嶇粓姝CZ696鐨勨參鏈烶ARADIGM-HF鐮旂┒銆?

NO.10Lampalizumab

鍏徃锛氱綏姘?

鐮斿彂闃舵锛氣叀鏈?

鑽悊绫诲埆锛氭姉琛ヤ綋鍥犲瓙D鍗曞厠闅嗘姉浣?

2020骞撮攢閲忥細11浜跨編鍏?

缃楁皬鐨勫勾榫勭浉鍏虫€ч粍鏂戝彉鎬?AMD)鏂拌嵂Lampalizumab鍙兘鍦ㄤ粖骞翠笅鍗婂勾杩涘叆鈪㈡湡涓村簥璇曢獙銆備腑鏈熼樁娈电粨鏋滄樉绀猴紝璇ヨ嵂鐨勭Н鏋佹暟鎹帴杩戝幓骞村悓鏈熸按骞炽€傜爺绌朵汉鍛樼О锛孡ampalizumab娌荤枟涓€涓湀鍚庡欢缂撲簡AMD鏅氭湡鎮ｈ€呯殑鐥呮儏杩涘睍锛岃鑽噺灏戜簡鐗瑰畾浜氱兢鐨勫湴鐞嗚悗缂?GA)鐜拌薄鍙揪20.4%锛屽湪18涓湀鏃跺湴鍥炬牱钀庣缉杩涘睍閫熷害缂╃煭浜?4%锛岃€屼笖娌℃湁鏄剧潃鍓綔鐢紝涓鸿鑽墿鐨勪笂甯傚瀹氳壇濂界殑鐮旂┒鍩虹銆?/p>