The ETS oncogene family in development, proliferation and neoplasia.

WS小青年

题名	The ETS oncogene family in development, proliferation and neoplasia.
作者	Hromas R, Klemsz M.
杂志	Int J Hematol.
年|卷|期	1994 Jun;59(4):257-65.
页码	1994 Jun;59(4):257-65.
链接	https://www.ncbi.nlm.nih.gov/pubmed/8086619

Int J Hematol. 1994 Jun;59(4):257-65.

The ETS oncogene family in development, proliferation and neoplasia.

Hromas R1, Klemsz M.

Abstract
V-ets was found as an oncogenic sequence in the E26 avian retrovirus, which produced leukemias in chickens. There are a large number of mammalian homologues of v-ets, all sharing a common sequence called the ETS domain. These mammalian homologues have been found to be transcriptional activators, and the ETS domain is the DNA binding portion of the gene. This family has been found to be important in regulating embryonic development and the response to growth stimuli. In addition, PU.1 and FLI-1 are dysregulated by Friend leukemia virus insertion in mice resulting in erythroleukemia. Significantly, the DNA binding portion of FLI-1 is the 3' part of an oncogenic fusion transcript (termed EWS-FLI) in human Ewing's sarcoma and neuroepithelioma.

PMID: 8086619