- 收听数
- 0
- 性别
- 保密
- 听众数
- 24
- 最后登录
- 2024-5-23
- 学历
- 硕士
- QQ
- UID
- 14792
- 阅读权限
- 10
- 帖子
- 169
- 精华
- 0
- 在线时间
- 56 小时
- 注册时间
- 2015-9-19
- 科研币
- 0
- 速递币
- 608
- 娱乐币
- 740
- 文献值
- 0
- 资源值
- 0
- 贡献值
- 0
|
yunzhongfeng 发表于 2016-10-8 16:32
ok
http://disk.680.com/nEFfye
Impact of blastocyst biopsy and comprehensive chromosome screening technology on preimplantation genetic screening: a systematic review of randomized controlled trials.
Dahdouh EM1, Balayla J2, García-Velasco JA3.
Author information
Abstract
Embryonic aneuploidy is highly prevalent in IVF cycles and contributes to decreased implantation rates, IVF cycle failure and early pregnancy loss. Preimplantation genetic screening (PGS) selects the most competent (euploid) embryos for transfer, and has been proposed to improve IVF outcomes. Use of PGS with fluorescence-in-situ hybridization technology after day 3 embryo biopsy (PGS-v1) significantly lowers live birth rates and is not recommended for use. Comprehensive chromosome screening technology, which assesses the whole chromosome complement, can be achieved using different genetic platforms. Whether PGS using comprehensive chromosome screening after blastocyst biopsy (PGS-v2) improves IVF outcomes remains to be determined. A systematic review of randomized controlled trials was conducted on PGS-v2. Three trials met full inclusion criteria, comparing PGS-v2 and routine IVF care. PGS-v2 is associated with higher clinical implantation rates, and higher ongoing pregnancy rates when the same number of embryos is transferred in both PGS and control groups. Additionally, PGS-v2 improves embryo selection in eSET practice, maintaining the same ongoing pregnancy rates between PGS and control groups, while sharply decreasing multiple pregnancy rates. These results stem from good-prognosis patients undergoing IVF. Whether these findings can be extrapolated to poor-prognosis patients with decreased ovarian reserve remains to be determined.
对不上
|
|