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速递书局
| 封面: |
 |
| 题名: |
Pharmaceutical Formulation Development of Peptides and Proteins, Second Edition |
| 作者: |
Lars Hovgaard, Sven Frokjaer, and Marco van de Weert |
| 出版社: |
CRC Press |
| 出版日期: |
2012 |
| ISBN: |
Print ISBN: 978-1-4398-5388-7；eBook ISBN: 978-1-4398-5389-4 |
| 附属页: |
齐全 |
| 书签: |
有 |
| 格式: |
清晰PDF |
| 内容简介: |
Features
Includes significant updates on new technology
Focuses on general pharmaceutical development aspects of peptides and proteins
Details the immunogenicity of protein pharmaceuticals
Addresses the biosimulation of pharmacokinetics and pharmacodynamics
Includes two new chapters: Immunogenicity of Protein Pharmaceuticals and Biosimulation of Pharmacokinetics and Pharmacodynamics
Summary
The rapid advances in recombinant DNA technology and the increasing availability of peptides and proteins with therapeutic potential are a challenge for pharmaceutical scientists who have to formulate these compounds as drug products.
Pharmaceutical Formulation Development of Peptides and Proteins, Second Edition discusses the development of therapeutic peptides and proteins, from the production of active compounds via basic pre-formulation and formulation to the registration of the final product.
Providing integrated solutions, this book discusses:
The synthesis of peptides and the biotechnological production of proteins through recombinant DNA technology
The physicochemical characteristics and stability of peptides and proteins
The formulation of proteins as suspensions, solutions, and (mostly freeze-dried) solids
The opportunities and challenges of non-parenteral delivery of peptides and proteins
Risk factors, specifically the development of an unwanted immune response
A simulation approach to describe the fate of peptides and proteins upon administration to a biological system
The documentation required to register a protein-based drug
Scientists in the pharmaceutical industry and academia as well as postgraduate students in pharmaceutical science will find this a valuable resource. |
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发表于 2014-8-12 17:43:39
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发表于 2014-8-12 17:51:38
