- 收听数
- 0
- 性别
- 保密
- 听众数
- 2
- 最后登录
- 2019-12-14
- QQ
 - UID
- 4456
- 阅读权限
- 100
- 帖子
- 5012
- 精华
- 0
- 在线时间
- 2664 小时
- 注册时间
- 2013-6-14
  
- 科研币
- 206
- 速递币
- 5739
- 娱乐币
- 8139
- 文献值
- 1035
- 资源值
- 50
- 贡献值
- 0
|
速递书局
| 封面: |
 |
| 题名: |
NMR Spectroscopy in Drug Development and Analysis |
| 作者: |
Ulrike Holzgrabe; Iwona Wawer; Bernd Diehl |
| 出版社: |
Wiley; |
| 出版日期: |
July 2008 |
| ISBN: |
9783527613656 |
| 附属页: |
齐全 |
| 书签: |
有 |
| 格式: |
清晰PDF |
| 内容简介: |
Since the development of the NMR spectrometer in the 1950s, NMR spectra have been widely used for the elucidation of the 2D structure of newly synthesized and natural compounds. In the 1980s, the high-resolution NMR spectrometer (> 300 Mhz) and 2D experiments were introduced, which opens up the possibility to determine the 3D structure of large molecules, especially biomolecules. However, NMR spectroscopy has been rarely applied to drug analysis.
This book illustrates the power and versatility of NMR spectroscopy in the determination of impurities in and the content of drugs, the composition of polymer excipients, the characterization of isomeric drug mixtures, the complexity of drugs with small-size components or ions, and the behavior of drugs in acid and basic solution. In addition, NMR spectroscopy and especially the hyphenated technique with HPLC is shown to be a powerful tool to measure a drug and its metabolites in various body fluids. The solid state NMR technique can give information on the structure, especially the conformation of drugs and excipients in drug formulations. Recently, SAR by NMR, introduced by Fesik, impressively demonstrated the potential of NMR spectroscopy in drug development and in the characterization of the interaction between large molecules and ligands. The complexation between proteins, lipids and cyclodextrins with drugs is described. Finally, NMR imaging (MRI and MRS) can be used to characterize the liberation of drugs from a drug formulation. Furthermore, the distribution of substances in plants, in animals, in tissues and in humans can be visualized by imaging.
In short, this book covers all aspects of drug analysis |
| 求助帖链接: |
- |
本帖子中包含更多资源
您需要 登录 才可以下载或查看，没有帐号？快速注册
-
总评分: 速递币 + 10
查看全部评分
|
发表于 2014-3-15 15:59:29
淘帖
收藏
顶
踩
