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发表于 2014-3-15 15:54:13 |只看该作者 |倒序浏览
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题名: Structure-Activity Relationship Studies in Drug Development by NMR Spectroscopy
作者: Atta-ur-Rahman(ed.) ; M. Iqbal Choudhary(ed.)
出版社: Bentham Science Publishers;
出版日期: July 2011
ISBN: 9781608051649
附属页: 齐全
书签:
格式: 清晰PDF
内容简介: NMR (Nuclear Magnetic Resonance) Spectroscopy has found significant applications in drug discovery based on its capacity to map molecular interactions at the atomic level. Chemical shifts, cross relaxation, and exchange of protons are among the NMR parameters which are highly sensitive to the exact environment of the molecules, and therefore yield information about whether a small molecule (candidate compound) binds to a target protein (receptor) or to other macromolecules. These NMR parameters are also used to exactly map the part of the macromolecular target to which the ligand is bound. Spectacular advances in the use of NMR spectroscopy in drug discovery and development have been triggered by a greater understanding of the disease process at the molecular level. Structure – Activity Relationship Studies in Drug Development by NMR Spectroscopy presents comprehensive reviews on NMR spectroscopic drug development written by leading experts in the field. This Ebook will fulfill an important need of the scientific community by providing recent cutting edge knowledge, practices and experiences in pharmaceutical innovation and development.
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